Microsoft Research has recently officially launched an AI research system for the life sciences field, Quine, positioning it as a "biological world model," aiming to accelerate the analysis of complex mechanisms and drug development through cross-scale biological reasoning.

The system consists of two core components: a biological world model and an interactive research platform. The underlying model is trained on multi-source heterogeneous data such as genomes, proteins, chemical molecules, RNA, cell states, and biological images, building a unified representation of life knowledge; the upper-level platform deeply integrates scientific literature, experimental tools, reasoning engines, and experimental scenarios, forming a human-computer collaboration research loop, prioritizing interventions and potential candidate pathways before expensive experiments are conducted.

QQ20260930-143637.jpg

In collaboration with Harvard University and the Broad Institute of MIT on pancreatic ductal adenocarcinoma, the research team used Quine to analyze and screen thousands of candidate compounds, completing the process from target intervention screening to wet lab validation within a single weekend. This not only validated the hypothesis of cell state transformation but also accurately predicted a previously overlooked new cell state.

Currently, Microsoft has also launched the Quine Fellows researcher program and plans to gradually integrate it into the Microsoft Discovery platform in the future. Microsoft clearly stated that the system is currently positioned as experimental research assistance and is not directly used for clinical medical decision-making. This achievement marks that generative AI is moving from single-point data fitting to a stage of research infrastructure with system-level reasoning capabilities.