Boltz-1

The first truly open-source biomolecular structure prediction model

CommonProductOthersBiomolecular structure predictionAlphaFold3

Boltz-1 is the first truly open-source biomolecular structure prediction model developed by researchers at the MIT Jameel Clinic for Health Machine Learning. Its accuracy is comparable to that of AlphaFold3. Named after the Boltzmann distribution, it serves as a probabilistic measure for describing the distribution of molecular structures. The development of Boltz-1 aims to foster innovation beyond academia and support commercial applications. Led by PhD students Jeremy Wohlwend, Gabriele Corso, and MIT Jameel Clinic researcher Saro Passaro, it was guided by MIT Electrical Engineering and Computer Science (EECS) professors Regina Barzilay and Tommi Jaakkola. Boltz-1 faced challenges regarding scale and data processing but ultimately constructed the necessary computational capacity, laying the foundation for standardizing structural biology research practices, with the potential to accelerate the creation of life-changing drugs.

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Boltz-1

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Boltz-1 — The first truly open-source biomolecular structure prediction model

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Boltz-1

Boltz-1 Visit Over Time

Boltz-1 Visit Trend

Boltz-1 Visit Geography

Boltz-1 Traffic Sources

Boltz-1 Alternatives

Boltz-1 — The first truly open-source biomolecular structure prediction model

AlphaFold Server — A high-precision biomolecular structure prediction platform based on the AlphaFold3 model

Open-source DeepResearch — An open-source deep research tool designed to replicate functionalities similar to Deep Research through an open-source framework.

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Gemma Open Models — A series of lightweight and advanced open-source models launched by Google.

AlphaFold 3 — AlphaFold 3, a joint AI model developed by Google DeepMind and Isomorphic Labs, is capable of accurately predicting the structures and interactions of all life molecules.

Open Source LLM Tools — A collection of open-source large language model tools.

Open Voice OS — Open-source voice AI platform

Chai-1 — An advanced multimodal foundational model for molecular structure prediction.

Stable Audio Open — Open-source audio samples and sound design models

OLMo — An open-source language model and training framework

Open Thoughts — A community project focused on curating the best open-source reasoning datasets

OpenAssistantGPT — An open-source platform for building chatbots

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